Drug May Be Non-Antibiotic Various to Deal with UTIs

FRIDAY, March 11, 2022 (HealthDay Information) — Ladies tormented by frequent urinary tract infections usually take every day antibiotics to ward them off. However an outdated antibiotic different may work simply as nicely, a brand new medical trial finds.

Researchers found that the remedy, known as methenamine, was comparable to plain, low-dose antibiotics in stopping ladies’s recurrent urinary tract infections (UTIs). Both remedy curbed the infections to round one per 12 months, on common.

Methenamine is a long-established remedy that works by making the urine extra acidic and stopping bacterial development. Research have proven that it may stop recurrent UTIs, but it surely’s not extensively used.

It is such an “outdated” drug, many medical doctors at the moment have no idea about it, mentioned Dr. Karyn Eilber, a urologist at Cedars-Sinai Medical Heart in Los Angeles.

Eilber, who was not concerned within the new examine, mentioned she reserves every day antibiotics as a final resort for stopping recurrent UTIs, favoring methenamine as an alternative.

A priority with every day antibiotic use is feeding antibiotic resistance, the place micro organism be taught to thwart the drugs used to kill them. Plus, Eilber mentioned, it disrupts the physique’s regular bacterial steadiness.

Dr. Chris Harding, a advisor urological surgeon at Freeman Hospital in the UK, led the trial.

See also  Crohn’s Disease

He mentioned it “provides supportive proof for using methenamine and might be notably welcome to these ladies with recurrent UTI who need to keep away from long-term antibiotic remedy.”

UTIs are exceedingly widespread and might have an effect on anybody, however are notably prevalent amongst ladies. Research recommend as much as 80% of ladies develop a UTI in some unspecified time in the future, and about one-quarter of these ladies go on to have frequent recurrences.

Some signs embrace burning throughout urination, and feeling a robust, persistent urge to urinate.

The brand new examine — printed on-line March 9 within theBMJ— concerned 240 ladies with recurring UTIs. At the beginning, they have been averaging round six UTIs per 12 months.

Half of the ladies have been randomly assigned to every day low-dose antibiotic remedy, whereas the opposite half took methenamine twice a day.

Over one 12 months of remedy, each teams noticed a major decline in UTI episodes. Ladies within the antibiotic group averaged just below one bout per particular person for the 12 months, whereas these taking methenamine had simply over one episode per particular person.

That could be a small distinction, Harding mentioned, and one which, primarily based on affected person focus teams, wouldn’t be thought-about “clinically significant.”

See also  Equal access to heart failure treatment for all

As for negative effects, a small variety of ladies in every group reported issues like nausea, stomach ache and diarrhea. Six ladies developed a UTI with fever, and 4 wanted to be hospitalized — all of whom have been within the methenamine group.

Whether or not treating extra UTIs with methenamine will assist battle the issue of antibiotic resistance is an open query. Through the one 12 months of remedy on this trial, ladies on antibiotics have been extra more likely to harbor micro organism immune to no less than one antibiotic. However that modified when their micro organism have been sampled six months later: Those that had taken methenamine had extra antibiotic-resistant bugs.

Harding mentioned that discovering “ought to be interpreted with warning,” for the reason that trial was not primarily geared toward gauging antibiotic resistance.

“Additional analysis is certainly indicated on this space,” he mentioned.

For now, ladies ought to know there are alternatives for stopping frequent UTIs, the specialists mentioned.

“Low-dose antibiotics ought to undoubtedly not be the primary line,” Eilber mentioned.

In addition to methenamine, one other different is to take an antibiotic solely after intercourse. (Sexual exercise can encourage UTI-causing micro organism to maneuver into the urethra, the tube that releases urine from the physique.)

See also  Holistic Program Might Assist Folks With Alzheimer's, Dementia

For postmenopausal ladies, Eilber mentioned, vaginal estrogen could assist stop recurrent UTIs. After menopause, the vaginal tissue adjustments in ways in which could foster the expansion of “unhealthy” micro organism.

Specialists additionally usually advise some self-care steps that may assist, like ingesting loads of water, urinating earlier than and after intercourse, and wiping entrance to again after utilizing the toilet.

Most of the ladies within the present trial have been going by means of or previous menopause. However, Harding mentioned, his staff didn’t have a look at the results of remedy in keeping with age. Nor did the examine embrace males. So it is not clear whether or not the findings would apply to older adults, one other group at elevated threat of recurrent UTI.

The examine was funded by the U.Ok. Nationwide Institute for Well being Analysis.

Extra data

The U.S. Workplace on Ladies’s Well being has extra on urinary tract infections.

SOURCES: Chris Harding, MD, advisor urological surgeon, Freeman Hospital, Newcastle upon Tyne, U.Ok.; Karyn Eilber, MD, urologist, Cedars-Sinai Medical Heart, Los Angeles; BMJ, March 9, 2022, on-line

Leave a Reply