Early Menopause Might Increase a Girl’s Odds for Dementia

TUESDAY, March 1, 2022 (HealthDay Information) — Ladies who enter menopause early could also be extra prone to develop dementia later in life, new analysis signifies.

Throughout menopause, manufacturing of the feminine intercourse hormone estrogen drops dramatically and a lady’s intervals come to an finish. Whereas girls sometimes enter menopause of their early 50s, many accomplish that earlier — both naturally or resulting from a medical situation or remedy corresponding to a hysterectomy (elimination of the uterus).

This huge examine discovered that ladies within the U.Okay. who entered menopause earlier than age 40 have been 35% extra prone to develop dementia later in life than girls who began menopause round age 50.

What’s extra, girls who entered menopause earlier than age 45 have been 1.3 occasions extra prone to develop dementia earlier than their sixty fifth birthday, the brand new examine confirmed.

“Ladies with early menopause may have an in depth monitoring of their cognitive decline in scientific follow,” stated examine creator Dr. Wenting Hao, a Ph.D. candidate at Shandong College in Jinan, China.

The upper threat for dementia could also be because of the sharp estrogen drop that takes place throughout menopause, Hao stated.

“Estrogen can activate mobile antioxidants corresponding to glutathione, scale back ApoE4, the most typical genetic threat issue within the pathogenesis of dementia, and scale back amyloid plaque deposition within the mind,” she defined.

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The build-up of amyloid plaques within the mind is without doubt one of the hallmarks of Alzheimer’s illness, the most typical sort of dementia.

This doesn’t imply that ladies who begin menopause early are powerless towards dementia, Hao stated.

“Dementia could be prevented, and there are a selection of how girls who expertise early menopause could possibly scale back their threat of dementia,” he stated. This consists of getting common train, collaborating in leisure and academic actions, not smoking or utilizing alcohol, and sustaining a wholesome weight, she stated.

For the examine, researchers in contrast age at menopause and dementia analysis amongst 153,291 girls (common age: 60) who have been a part of the UK Biobank, a big database of genetic and well being data on folks residing in the UK. They regarded for every type of dementia, together with Alzheimer’s.

Postmenopausal girls are at better threat of stroke than pre-menopausal girls, and stroke might trigger vascular dementia, however the examine discovered no hyperlink between age at menopause and the danger of this kind of dementia.

Whereas girls who entered menopause early have been at increased threat of dementia, those that entered menopause at age 52 or later had comparable charges of dementia as girls who began menopause at age 50 or 51, the examine confirmed.

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The brand new findings held after researchers accounted for different components which will enhance dementia threat, together with age eventually examination, race, schooling, cigarette and alcohol use, physique fats, coronary heart illness, diabetes, revenue and leisure and bodily actions. The examine didn’t embody data on whether or not girls had a household historical past of dementia or if girls entered menopause early for pure or medical causes, which might have an effect on the findings.

The findings have been introduced Tuesday at a gathering of the American Coronary heart Affiliation held in Chicago and on-line. Analysis introduced at medical conferences is usually thought of preliminary till revealed in a peer-reviewed journal.

These findings are in line with different research exhibiting a better threat of dementia amongst girls with untimely or early menopause, stated Dr. Stephanie Faubion, medical director of the North American Menopause Society and director of the Mayo Clinic Heart for Ladies’s Well being.

“The early lack of estrogen is linked with an elevated threat of a number of antagonistic long-term well being outcomes, and dementia is only one of them,” stated Faubion. Others embody coronary heart illness, brittle bone illness, osteoporosis, temper issues, sexual dysfunction and early loss of life.

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There could also be a job for hormone substitute remedy, she stated.

“Along with suggesting monitoring of those girls, changing estrogen is a key technique and has been proven to mitigate dementia threat (and different dangers) in girls with untimely or early menopause,” Faubion stated.

For years, hormone replacement therapy was broadly prescribed to deal with signs of menopause and decrease threat for coronary heart illness, osteoporosis and dementia. This all modified when the landmark Ladies’s Well being Initiative examine confirmed that taking estrogen and progestin after menopause might improve girls’s threat for stroke, coronary heart illness, blood clots and breast most cancers. (Estrogen helps with menopause signs like sizzling flashes and vaginal dryness, and progestin is added to guard towards uterine most cancers in girls who nonetheless have a uterus.)

At present, hormone substitute remedy could also be prescribed within the lowest dose for the shortest period of time to maximise advantages and decrease potential dangers.

Extra data

The Alzheimer’s Affiliation gives recommendations on stopping dementia.


SOURCES: Wenting Hao, MD, PhD candidate, Shandong College, Jinan, China.; Stephanie Faubion, MD, MBA, director, Heart for Ladies’s Well being, Mayo Clinic, Rochester, Minn., and Jacksonville, Fla., and medical director, North American Menopause Society; March 1, 2022, presentation, American Coronary heart Affiliation assembly, Chicago

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